Follistatin 315 1mg Peptide Vial United States
Follistatin 315 is a naturally occurring peptide known for its ability to bind to activin and myostatin, proteins that typically suppress muscle growth. This binding action essentially inhibits the suppression of muscle growth, thereby promoting both hypertrophy (increased size of muscle cells) and hyperplasia (increased number of muscle cells).
There are two primary isoforms of follistatin, generated by alternative splicing. One of these, the FS-344 variant, undergoes peptide cleavage to generate Follistatin 315 . Notably, FS-315 is the predominant form of follistatin in circulation, making up approximately 95% of all follistatins .
United States Studies have shown that treatment with the Follistatin 315 protein isoform can lead to significant increases in muscle mass and strength, even when administered to older mice undergoing repeated cycles of muscle wasting . This suggests potential therapeutic applications for conditions characterized by muscle loss or weakness.
Follistatin 315 primarily targets muscle tissue, which suggests it may be the most effective isoform for muscle-related applications. Additionally, a slightly truncated form of the FS315 protein, known as FS303, is produced by cleavage of part of the C-terminal. It is generally believed that FS315 and/or FS303 are the active forms of follistatin .
A fraction of follistatin 315 is further converted to the 303 amino acid form by proteolytic cleavage at the C-terminus. These multiple forms and variants of follistatin contribute to its complex role in muscle growth and development .
Furthermore, Follistatin 315 has been found in United States studies to inhibit the activity of a wide range of hormones and proteins, including activins, myostatin and Follicle-stimulating hormone (FSH) . In addition to this, the peptide has also demonstrated it’s ability to enhance fertility and help shed body fat in both women and men.
In conclusion, Follistatin 315 is a potent regulator of muscle growth, acting to inhibit proteins that suppress muscle development. Its potential therapeutic applications in muscle diseases make it a significant focus of ongoing research.
 https://www.ncbi.nlm.nih.gov/pmc/ articles/PMC2393740/
 https://www.nature.com/articles/ emm2017135
 https://www.sciencedirect.com/ topics/neuroscience/follistatin
 https://atlasgeneticsoncology.org/ gene/44477/fst-(follistatin)
 https://pubmed.ncbi.nlm.nih.gov/ 9395712/
Sequence: G NCWLRQAKNG RCQVLYKTEL SKEECCSTGR LSTSWTEEDV NDNTLFKWMI FNGGAPNCIP CKETCENVDC GPGKKCRMNK KNKPRCVCAP DCSNITWKGP VCGLDGKTYR NECALLKARC KEQPELEVQY QGRCKKTCRD VFCPGSSTCV VOCITNNAYCV TCNRICPEPA SSEQYLCGND GVTYSSACHL RKATCLLGRS IGLAYEGKCI KAKSCEDIOC TGGKKCLWDF KVGRGRCSLC DELCPDSKSD EPVCASDNAT YASECAMKEA ACSSGVLLEV KHSGSCNSIS EDTEEEEEDE DODYSFPISS ILEW
Molecular Weight: 3470
Storage: Lyophilized peptides store below -18°C
Research use only. Not for human or animal consumption!
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