Buy Tesofensine Peptide United States

Q: Is Tesofensine a Peptide?

Tesofensine is not a peptide, it belongs to the phenyltropane family, which was first developed to combat cocaine addiction. These drugs aimed to mimic cocaine’s stimulation without its addictive effects, targeting the central nervous system to avoid dependency. Its development focus explains why TE affects neurotransmission, especially dopamine pathways involved in reward and addiction. Research indicates that tesofensine doesn’t possess qualities that would make it attractive for recreational use, effectively lowering the addictive potential of such stimulants.

Q: Where can I buy Tesofensine?

You can buy Tesofensine from reputable suppliers such as Direct Peptides, which ensures the product’s quality through stringent testing protocols. It is essential to buy Tesofensine from credible sources to guarantee the safety and efficacy of the product.

Q: What are the side effects of Tesofensine?

Tesofensine, like other weight loss drugs, may cause side effects such as insomnia, dry mouth, constipation, tachycardia, diarrhoea, nausea, increased heart rate, and high blood pressure, highlighting the need for medical supervision.

Q: Can Tesofensine Cause Addiction?

Extensive research shows that Tesofensine is not addictive, making it a promising compound for further study. Researchers should buy Tesofensine from reputable sources to ensure its integrity. Adhering to dosage guidelines and rigorous monitoring is crucial for safe administration in clinical studies. Strict oversight allows exploration of Tesofensine’s effectiveness and safety, providing valuable insights to the scientific community.

Q: Is Tesofensine legal?

The legality of Tesofensine varies by country and its pharmaceutical regulations. In some places, it may be approved for specific medical use, while in others, it remains under investigation. The FDA (Food and Drug Administration) in the U.S. has not approved Tesofensine for human consumption, and its legal status is still under review. Consult applicable laws in accordance with your local regulatory authorities to understand its legal status in your area. It’s also important to buy Tesofensine from reputable sources and follow local legal guidelines to ensure safety and compliance.

Q: How should Tesofensine be stored?

Tesofensine should be stored in a cool, dry place, away from direct sunlight and moisture. Ideal storage conditions are typically outlined by the manufacturer, but generally, keeping the capsules in a temperature-controlled environment between 15°C and 25°C (59°F and 77°F) is recommended. Always ensure the container is tightly sealed and out of reach of children and pets. Following proper storage guidelines helps maintain the integrity and efficacy of Tesofensine.

Tesofensine is a serotonin noradrenaline dopamine reuptake inhibitor (SNDRI) from the phenyltropane family of drugs. Designed to treat obesity, it works by reducing appetite and boosting fat metabolism, making it effective for weight loss.

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What Is Tesofensine?

Tesofensine (TE) is a drug originally developed to treat neurodegenerative diseases like Alzheimer’s and Parkinson’s disease. However, during clinical trials, researchers discovered that it had a significant effect on weight loss. The biological activity of Tesofensine works by inhibiting the reuptake of three neurotransmitters: serotonin, norepinephrine and dopamine receptors.

By preventing the reuptake of serotonin, dopamine, and norepinephrine, it increases the levels of these neurotransmitter systems in the brain. This action can help suppress appetite and boost energy expenditure, leading to weight loss. Because of its potential as an anti-obesity medication, tesofensine has been studied in clinical trials for weight management.

Studies have demonstrated this multifaceted approach has helped obese individuals achieve substantial weight loss in clinical outcomes. However, it is not yet widely approved for use as a weight-loss supplement. Like any medication, it may have side effects, including increased heart rate and blood pressure, so it is currently only sold for research use and clinical development. These capsules require careful United States medical supervision.

Source:PubChem

Structure of Tesofensine

Sequence: It is not classified as a peptide.

Molecular Formula: C17H23Cl2NO

Molecular Weight: 328.3 g/mol

PubChem CID: 11370864

Tesofensine Mechanism Of Action

Tesofensine works through a triple reuptake inhibition mechanism, targeting three crucial monoaminergic neurotransmitters: serotonin, dopamine, and norepinephrine. According to United States research, by impeding the process through which these neurotransmitters are reabsorbed into the nerve cells in the brain, tesofensine increases their availability within the synaptic gap. This elevated presence of neurotransmitters enhances neural communication, particularly in brain regions associated with appetite regulation and metabolic processes.

Consequently, the enhanced neurotransmitter activity contributes to reduced appetite and potentially increases metabolic rate, leading to weight loss. This tripartite approach distinguishes tesofensine from other weight management medications, which typically target a single neurotransmitter pathway.

Initial clinical trials have demonstrated promising results regarding tesofensine’s efficacy in promoting significant weight loss, surpassing that of currently available medications. Nonetheless, ongoing United States research and comprehensive clinical trials are essential to fully understand its safety profile, potential side effects, and long-term impacts on obesity and related metabolic disorders.

What Are The Research Benefits of Tesofensine 500mcg?

Weight Loss

Optimal Conditions: It works best when combined with caloric restrictions and exercise, though weight loss still occurs without these changes.
Clinical Trial Results: In one trial, men lost 1.8 kg in two weeks of treatment with the compound while maintaining their usual diet and activity, compared to placebo.
Increased Satiety: Participants reported increased satiety and reduced appetite.
Energy Expenditure: There was a nearly 5% higher energy expenditure during sleep compared to placebo, correlating with increased fat oxidation.
Appetite Control: United States Research reveals satiety is centrally controlled and challenging to modify permanently, with tesofensine significantly reducing food intake and appetite.
Effect of Discontinuation: Discontinuing TE returns sensations to baseline, but reintroduction suppresses them again, indicating appetite sensations are more permanent.
Hunger Mitigation: It mitigates persistent hunger signals, showing significant weight loss in clinical trials.
Longevity of Effects: Unlike other appetite-affecting compounds, it’s effects diminish but do not stop completely. It has longer-lasting effects than other aids with substantial rebound to baseline after a short break.
Potential for Cycled Use: No long-term trials on cycled TE have been conducted, but evidence suggests that appropriately cycled use might result in even greater weight loss.

Pain Management

The use of antidepressants in pain management is well-documented. Tri-cyclic antidepressants, early drugs for mood disorders, are known to reduce pain perception, especially in conditions like fibromyalgia. United States Research shows that the pain-relief effects of standard antidepressants, which affect serotonin and norepinephrine, are boosted by adding dopamine agents. This leads to the hypothesis that triple reuptake inhibitors like tesofensine may benefit pain management.

Blood Sugar

A recent study in rats has shown that it improves glycemic control and reduces insulin response, aiding in weight loss. By moderating insulin’s effect on fat storage, it helps prevent fat accumulation even with high blood sugar levels. Tesofensine also breaks the cycle of fat deposition and inflammation, balancing metabolism and combating adiposity.

Cognitive Health

Despite it’s discontinuation for neurodegenerative diseases, evidence shows benefits in cognitive function, memory, and neurogenesis. One United States study showed it enhances brain-derived neurotrophic factor (BDNF) in rat models, promoting neurogenesis and synaptic transmission. Altered BDNF signaling is linked to several mental health conditions. This underscores the necessity for future research to examine it’s effects on BDNF and brain health, emphasizing the importance of further exploration into its mechanisms and potential benefits.

Mood Disorders

Known for its dopaminergic and anti-obesity effects, it may also have antidepressant properties by improving BDNF levels and promoting neurogenesis in the hippocampus. This dual action makes it a promising treatment for individuals facing both weight and mood disorders, addressing depression linked to stress-induced hippocampal atrophy.

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Further Answered Questions (FAQ’s) about Tesofensine

Is Tesofensine a Peptide?

It is not a peptide, it belongs to the phenyltropane family, which was first developed to combat cocaine addiction. These drugs aimed to mimic cocaine’s stimulation without its addictive effects, targeting the central nervous system to avoid dependency.

Its development focus explains why TE affects neurotransmission, especially dopamine pathways involved in reward and addiction. United States Research shows that it lacks qualities that make it appealing for recreational use, which significantly reduces its addictive potential.

Where can I buy Tesofensine?

You can buy Tesofensine from reputable suppliers such as United States Direct Peptides, which ensures the product’s quality through stringent testing protocols. It is essential to buy Tesofensine from credible sources to guarantee the safety and efficacy of the product.

What are the benefits of Tesofensine?

In clinical trials, TE, combined with a calorie-restricted diet and daily exercise, showed significant benefits. Participants saw a decrease in body weight and BMI, improved waist-to-hip ratios, lower triglycerides and very low-density lipoprotein levels, and a significant reduction in body and visceral fat. There was also evidence of a reversing effect on type 2 diabetes.

Can Tesofensine Cause Addiction?

Extensive research shows that it is not addictive, making it a promising compound for further study. United States Researchers should buy Tesofensine from reputable sources to ensure its integrity. Adhering to dosage guidelines and rigorous monitoring is crucial for safe administration in clinical studies. Strict oversight allows exploration of it’s effectiveness and safety, providing valuable insights to the scientific community.

What are the side effects of Tesofensine?

Like other weight loss drugs, it may cause an adverse event such as insomnia, dry mouth, constipation, tachycardia, diarrhoea, nausea, increased heart rate, and high blood pressure, highlighting the need for medical supervision.

Is Tesofensine legal?

The legality varies by country and its pharmaceutical regulations. In some places, it may be approved for specific medical use, while in others, it remains under investigation. The FDA (Food and Drug Administration) in the U.S. has not approved it for human consumption, and its legal status is still under review. Consult applicable laws in accordance with your local regulatory authorities to understand its legal status in your area. It’s also important to buy Tesofensine from reputable sources and follow local legal guidelines to ensure safety and compliance.

How should Tesofensine be stored?

It should be stored in a cool, dry place, away from direct sunlight and moisture. Ideal storage conditions are typically outlined by the manufacturer, but generally, keeping the capsules in a temperature-controlled environment between 15°C and 25°C (59°F and 77°F) is recommended. Always ensure the container is tightly sealed and out of reach of children and pets. Following proper storage guidelines helps maintain the integrity and efficacy of Tesofensine.

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Tesofensine 500mcg Capsules for sale from Direct Peptides United States

Summary of Research Applications

Appetite Suppressant.
Improved Weight Loss.
Enhanced Energy Levels
Neuroprotective Benefits.
Antidepressant Effects.

Tesofensine Quality Assured

Buy Tesofensine 0.5 mg peptides with 99% purity from Direct Peptides, designed for top-quality research. Our products are third party tested for potency and reliability, providing consistent results to support accurate and precise research outcomes.

References For Further Reading

[1] K A Schoedel, D Meier, B Chakraborty, P M Manniche, E M Sellers (2010) Subjective and objective effects of the novel triple reuptake inhibitor tesofensine in recreational stimulant users – Clinical Pharmacology and Therapeutics, 2010 Jul;88(1):69-78.

[2] A.Astrup, D.H.Meier, B.O.Mikkelsen, et al (2008) Weight loss produced by tesofensine in patients with Parkinson’s or Alzheimer’s disease – Obesity (a research journal) Silver Spring Md, vol. 16, no. 6, pp. 1363–1369, Jun. 2008.

[3] M.H.Larsen, H.Rosenbrock, F.Sams-Dodd, and J.D.Mikkelsen (2007) Expression of brain derived neurotrophic factor, activity-regulated cytoskeleton protein mRNA, and enhancement of adult hippocampal neurogenesis in rats after sub-chronic and chronic treatment with the triple monoamine re-uptake inhibitor tesofensine – European Journal of Pharmacology, 2007 Jan 26;555(2-3):115-21.

[4] A.Astrup, S.Madsbad, L.Breum et al (2008) Effect of tesofensine on bodyweight loss, body composition, and quality of life in obese patients: a randomised, double-blind, placebo-controlled trial – Lancet Journal, 2008 Nov 29;372(9653):1906-1913.

[5] AB.Saniona (2018) Saniona’s tesofensine meets primary and secondary endpoints in Phase 3 obesity registration trial – Press Releases from GlobeNewswire News Room, Dec. 17, 2018.

[6] J.A.Gilbert, C.Gasteyger, A.Raben, et al (2012) The effect of tesofensine on appetite sensations – Obesity (Silver Spring Md) volume 20, no. 3, pp. 553–561, Mar. 2012.

[7] L.Appel, M.Bergström, J.B.Lassen, and B.Långström (2014) Tesofensine, a novel triple monoamine re-uptake inhibitor with anti-obesity effects: Dopamine transporter occupancy as measured by PET – European Neuropsychopharmacology, Volume 24, Issue 2, February 2014, Pages 251-261.

[8] A.Sjödin, C.Gasteyger, A.Lh.Nielsenet et al (2010) The effect of the triple monoamine reuptake inhibitor tesofensine on energy metabolism and appetite in overweight and moderately obese men – International Journal of Obesity, volume 34, no. 11, pp. 1634–1643, Nov. 2010.

[9] Anne Marie D Axel, Jens D Mikkelsen, and Henrik H Hansen (2010) Tesofensine, a novel triple monoamine reuptake inhibitor, induces appetite suppression by indirect stimulation of alpha1 adrenoceptor and dopamine D1 receptor pathways in the diet-induced obese rat – Neuropsychopharmacology, 2010 Jun, Volume 35 (Issue 7), Pages 1464-76.

[10] S.M.Korte, J.Prins, A.M.Krajnc et al (2015) The many different faces of major depression: it is time for personalized medicine – European Journal of Pharmacology, 2015 Apr 15:753:88-104.

[11] Ł.R.Drzyzga, A.Marcinowska, and E.Obuchowicz (2009) Antiapoptotic and neurotrophic effects of antidepressants: a review of clinical and experimental studies – Brain Research Bulletin, Volume 79, Issue 5, 30 June 2009, Pages 248-257.

[12] D.M.Marks, C.U.Pae, and A.A.Patkar (2008) Triple Reuptake Inhibitors: The Next Generation of Antidepressants – Current Neuropharmacology, 2008 Dec; 6(4): 338–343.

[13] A.Astrup, S.Madsbad, L.Breum et al (2013) Under-reporting of adverse effects of tesofensine – The Lancet Jounral, Correspondence, Volume 382, Issue 9887, P127, July 13, 2013.

[14] B.M.Yung Cheung, T.Tsang Cheung, N.R.Samaranayake (2013) Safety of antiobesity drugs – Therapeutic Advances in Drug Safety, 2013 Aug 4, (4):171-81.

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DISCLAIMER: These products are intended solely as a research chemical only. This classification allows for their use only for research development and laboratory studies. The information available on our United States Direct Peptides website: https://united-states.direct-peptides.com is provided for educational purposes only. These products are not for human or animal use or consumption in any manner. Handling of these products should be limited to suitably qualified professionals. They are not to be classified as a drug, food, cosmetic, or medicinal product and must not be mislabelled or used as such.