AICAR, or 5-aminoimidazole-4-carboxamide ribonucleotide, is a peptide that has gained attention as a promising therapeutic agent with diverse potential applications, particularly in conditions related to muscle function and metabolism. AICAR peptide acts primarily as an AMPK activator (AMP-activated protein kinase),a regulator of cellular energy homeostasis which plays a crucial role in glucose and lipid metabolism.
In addition to its effects on muscle metabolism, AICAR also exhibits cardioprotective properties. It has been shown to reduce the size of myocardial infarction and improve post-ischemic heart function, potentially via the activation of AMPK and the subsequent inhibition of apoptosis.
AICAR is also being studied as a possible treatment for diabetes, autoimmune diseases, and other inflammatory conditions.
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